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This opens up the possibility of our gene therapy targeting the GSH system

Think of it as turning down the flow of incoming calories

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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

KINOMEscan and off-target profiling confirmed its selectivity and minimal off-target interactions (Supplementary Fig

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